Assay Detail
Binding
CHEMBL759444
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Maximum transcriptional activation of human PPAR gamma receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)--synthesis and biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.43 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38943 | GW501516 | 2.0 | 1 | 6.07 |
| CHEMBL38508 | — | — | 1 | 5.70 |
| CHEMBL40614 | — | — | 1 | 5.57 |
| CHEMBL39687 | — | — | 1 | 5.48 |
| CHEMBL39894 | — | — | 1 | 5.38 |
| CHEMBL288341 | — | — | 1 | 5.15 |
| CHEMBL39129 | — | — | 1 | 5.10 |
| CHEMBL416794 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38943 | GW501516 | EC50 | = | 850.0 | nM | 6.07 |
| CHEMBL38508 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL40614 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL39687 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL39894 | — | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL288341 | — | EC50 | = | 7040.0 | nM | 5.15 |
| CHEMBL39129 | — | EC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL416794 | — | EC50 | = | 9800.0 | nM | 5.01 |