Assay Detail
Functional
CHEMBL759446
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Peroxisome proliferator activated receptor gamma agonistic activity in HepG2 cells.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HepG2 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel oximes having 5-benzyl-2,4-thiazolidinedione as antihyperglycemic agents: synthesis and structure-activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 5.91 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL123749 | — | — | 1 | 6.72 |
| CHEMBL125659 | — | — | 1 | 6.48 |
| CHEMBL125176 | — | — | 1 | 6.40 |
| CHEMBL125895 | — | — | 1 | 6.19 |
| CHEMBL843 | ROSIGLITAZONE MALEATE | 4.0 | 1 | 6.14 |
| CHEMBL125894 | — | — | 1 | 6.10 |
| CHEMBL124421 | — | — | 1 | 5.96 |
| CHEMBL121719 | — | — | 1 | 5.80 |
| CHEMBL123257 | — | — | 1 | 5.80 |
| CHEMBL338390 | — | — | 1 | 5.77 |
| CHEMBL341105 | — | — | 1 | 5.55 |
| CHEMBL125177 | — | — | 1 | 5.55 |
| CHEMBL1715 | PIOGLITAZONE HYDROCHLORIDE | 4.0 | 1 | 5.12 |
| CHEMBL125363 | — | — | 1 | 5.10 |
| CHEMBL124790 | — | — | 1 | - |
| CHEMBL123579 | — | — | 1 | - |
| CHEMBL338211 | — | — | 1 | - |
| CHEMBL123268 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL123749 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL125659 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL125176 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL125895 | — | EC50 | = | 640.0 | nM | 6.19 |
| CHEMBL843 | ROSIGLITAZONE MALEATE | EC50 | = | 730.0 | nM | 6.14 |
| CHEMBL125894 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL124421 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL121719 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL123257 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL338390 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL341105 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL125177 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1715 | PIOGLITAZONE HYDROCHLORIDE | EC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL125363 | — | EC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL124790 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL123579 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL338211 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL123268 | — | EC50 | > | 100000.0 | nM | - |