Assay Detail
Binding
CHEMBL759454
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In vitro binding affinity for human PPAR gamma in SPA
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Phenylacetic acid derivatives as hPPAR agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.73 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23874 | — | — | 1 | 7.32 |
| CHEMBL278994 | L-796449 | — | 1 | 7.03 |
| CHEMBL279053 | L-165461 | — | 1 | 6.96 |
| CHEMBL23296 | — | — | 1 | 6.85 |
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | 6.68 |
| CHEMBL25710 | — | — | 1 | 6.52 |
| CHEMBL23670 | — | — | 1 | 6.25 |
| CHEMBL23881 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23874 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL278994 | L-796449 | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL279053 | L-165461 | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL23296 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL121 | ROSIGLITAZONE | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL25710 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL23670 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL23881 | — | IC50 | = | 580.0 | nM | 6.24 |