Assay Detail
Binding
CHEMBL759581
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In vitro inhibition against human full length PARP protein
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Resistance-modifying agents. 9. Synthesis and biological properties of benzimidazole inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 34 | 7.69 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL334734 | — | — | 1 | 8.92 |
| CHEMBL133241 | — | — | 1 | 8.80 |
| CHEMBL338923 | — | — | 1 | 8.70 |
| CHEMBL131891 | — | — | 1 | 8.52 |
| CHEMBL335993 | — | — | 1 | 8.40 |
| CHEMBL133343 | — | — | 1 | 8.27 |
| CHEMBL334357 | — | — | 1 | 8.24 |
| CHEMBL337386 | — | — | 1 | 8.23 |
| CHEMBL134022 | — | — | 1 | 8.22 |
| CHEMBL131719 | — | — | 1 | 8.22 |
| CHEMBL336070 | — | — | 1 | 8.20 |
| CHEMBL337254 | — | — | 1 | 8.17 |
| CHEMBL131820 | — | — | 1 | 8.17 |
| CHEMBL335516 | — | — | 1 | 8.10 |
| CHEMBL133855 | — | — | 1 | 8.09 |
| CHEMBL132947 | — | — | 1 | 8.08 |
| CHEMBL133353 | — | — | 1 | 8.05 |
| CHEMBL335226 | — | — | 1 | 8.03 |
| CHEMBL134116 | — | — | 1 | 8.03 |
| CHEMBL133275 | — | — | 1 | 7.97 |
| CHEMBL134197 | — | — | 1 | 7.96 |
| CHEMBL133976 | — | — | 1 | 7.89 |
| CHEMBL81723 | — | — | 1 | 7.82 |
| CHEMBL131737 | — | — | 1 | 7.50 |
| CHEMBL341427 | — | — | 1 | 7.07 |
| CHEMBL133694 | — | — | 1 | 7.02 |
| CHEMBL121765 | — | — | 1 | 7.00 |
| CHEMBL423343 | — | — | 1 | 6.90 |
| CHEMBL132834 | — | — | 1 | 6.87 |
| CHEMBL334603 | — | — | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL334734 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL133241 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL338923 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL131891 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL335993 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL133343 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL334357 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL337386 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL134022 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL131719 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL336070 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL337254 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL131820 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL335516 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL133855 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL132947 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL133353 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL335226 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL134116 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL133275 | — | Ki | = | 10.6 | nM | 7.97 |
| CHEMBL134197 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL133976 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL81723 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL131737 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL341427 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL133694 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL121765 | — | Ki | = | 99.0 | nM | 7.00 |
| CHEMBL423343 | — | Ki | = | 126.0 | nM | 6.90 |
| CHEMBL132834 | — | Ki | = | 136.0 | nM | 6.87 |
| CHEMBL334603 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL335198 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL133096 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL338955 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL336859 | — | Ki | = | 100000.0 | nM | 4.00 |