Assay Detail
Functional
CHEMBL759626
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In vitro cytotoxicity against human prostate carcinoma (PC-3) cell line
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
New analogues of amonafide and elinafide, containing aromatic heterocycles: synthesis, antitumor activity, molecular modeling, and DNA binding properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.85 | 6.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285957 | — | — | 1 | 6.79 |
| CHEMBL31400 | ELINAFIDE | 2.0 | 1 | 6.50 |
| CHEMBL284772 | — | — | 1 | 6.40 |
| CHEMBL27684 | — | — | 1 | 6.30 |
| CHEMBL31260 | — | — | 1 | 6.03 |
| CHEMBL32087 | — | — | 1 | 5.92 |
| CHEMBL24824 | — | — | 1 | 5.85 |
| CHEMBL32062 | — | — | 1 | 5.60 |
| CHEMBL285372 | — | — | 1 | 5.46 |
| CHEMBL284108 | — | — | 1 | 5.25 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 5.20 |
| CHEMBL27683 | — | — | 1 | 4.90 |
| CHEMBL11025 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285957 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL31400 | ELINAFIDE | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL284772 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL27684 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL31260 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL32087 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL24824 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL32062 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL285372 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL284108 | — | IC50 | = | 5580.0 | nM | 5.25 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 6380.0 | nM | 5.20 |
| CHEMBL27683 | — | IC50 | = | 12580.0 | nM | 4.90 |
| CHEMBL11025 | — | IC50 | > | 100000.0 | nM | - |