Assay Detail
Functional
CHEMBL759672
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In vitro inhibitory activity against multidrug-resistant Plasmodium falciparum W2 Indochina
32
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and effects on chloroquine susceptibility in Plasmodium falciparum of a series of new dihydroanthracene derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 4.83 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.05 |
| CHEMBL321238 | — | — | 2 | 5.70 |
| CHEMBL322320 | — | — | 1 | 5.60 |
| CHEMBL321924 | — | — | 1 | 5.40 |
| CHEMBL111076 | ANTHRACENE40 | — | 1 | 5.10 |
| CHEMBL108992 | — | — | 1 | 5.10 |
| CHEMBL324178 | — | — | 1 | 5.10 |
| CHEMBL440892 | — | — | 1 | 5.10 |
| CHEMBL323158 | — | — | 1 | 5.03 |
| CHEMBL321034 | — | — | 1 | 5.00 |
| CHEMBL110097 | — | — | 2 | 4.91 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 4.87 |
| CHEMBL108087 | — | — | 1 | 4.80 |
| CHEMBL643 | PROMETHAZINE | 4.0 | 1 | 4.70 |
| CHEMBL111746 | — | — | 1 | 4.68 |
| CHEMBL324180 | — | — | 1 | 4.52 |
| CHEMBL320546 | — | — | 1 | 4.50 |
| CHEMBL1627157 | — | — | 1 | 4.48 |
| CHEMBL323489 | — | — | 1 | 4.47 |
| CHEMBL418821 | — | — | 1 | 4.44 |
| CHEMBL108191 | — | — | 1 | 4.44 |
| CHEMBL322258 | — | — | 1 | 4.39 |
| CHEMBL324010 | — | — | 1 | 4.36 |
| CHEMBL108041 | — | — | 1 | 4.30 |
| CHEMBL111325 | — | — | 1 | 4.29 |
| CHEMBL267936 | MECAMYLAMINE | 4.0 | 1 | 4.04 |
| CHEMBL107867 | — | — | 1 | - |
| CHEMBL324905 | — | — | 1 | - |
| CHEMBL424619 | — | — | 1 | - |
| CHEMBL108596 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL321238 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL322320 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL321924 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL321238 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL111076 | ANTHRACENE40 | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL108992 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL324178 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL440892 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL323158 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL321034 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL110097 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL108087 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL643 | PROMETHAZINE | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL111746 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL324180 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL320546 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL1627157 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL323489 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL110097 | — | IC50 | = | 35500.0 | nM | 4.45 |
| CHEMBL418821 | — | IC50 | = | 36500.0 | nM | 4.44 |
| CHEMBL108191 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL322258 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL324010 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL108041 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL111325 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL267936 | MECAMYLAMINE | IC50 | = | 91400.0 | nM | 4.04 |
| CHEMBL107867 | — | IC50 | = | 302000.0 | nM | - |
| CHEMBL324905 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL424619 | — | IC50 | = | 164000.0 | nM | - |
| CHEMBL108596 | — | IC50 | = | 833000.0 | nM | - |