Assay Detail
Binding
CHEMBL759681
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Phosphodiesterase 3 from human platelets at 1E-7-1E-4M or 1.0E-6 to 1E-3 M
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Cardiotonic agents. 9. Synthesis and biological evaluation of a series of (E)-4,5-dihydro-6-[2-[4-(1H-imidazol-1-yl)phenyl]ethenyl]-3 (2H)-pyridazinones: a novel class of compounds with positive inotropic, antithrombotic, and vasodilatory activities for the treatment of congestive heart failure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.84 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119237 | — | — | 1 | 7.75 |
| CHEMBL440593 | CI-930 | — | 1 | 6.40 |
| CHEMBL333598 | — | — | 1 | 6.06 |
| CHEMBL189 | MILRINONE | 4.0 | 1 | 5.96 |
| CHEMBL12856 | INAMRINONE | 4.0 | 1 | 4.80 |
| CHEMBL117783 | — | — | 1 | 4.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119237 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL440593 | CI-930 | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL333598 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL189 | MILRINONE | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL12856 | INAMRINONE | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL117783 | — | IC50 | = | 87000.0 | nM | 4.06 |