Assay Detail
Binding
CHEMBL759683
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Inhibitory concentration against phosphodiesterase 3 from human platelet
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Identification of purine inhibitors of phosphodiesterase 7 (PDE7).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.59 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34431 | CILOSTAMIDE | 2.0 | 1 | 8.00 |
| CHEMBL313842 | ZARDAVERINE | 2.0 | 1 | 6.96 |
| CHEMBL100779 | — | — | 1 | 6.24 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 5.16 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | - |
| CHEMBL516604 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34431 | CILOSTAMIDE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL313842 | ZARDAVERINE | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL100779 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL192 | SILDENAFIL | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL63 | ROLIPRAM | IC50 | > | 10000.0 | nM | - |
| CHEMBL516604 | — | IC50 | > | 10000.0 | nM | - |