Assay Detail
Binding
CHEMBL759725
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro transcriptional activation in CV-1 cells expressing human Gal4-PPAR delta ligand binding domain
13
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor delta (CHEMBL3979) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 5.57 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20392 | — | — | 1 | 5.96 |
| CHEMBL278590 | GSK-9578 | — | 1 | 5.85 |
| CHEMBL20125 | — | — | 2 | 5.70 |
| CHEMBL20495 | — | — | 1 | 5.40 |
| CHEMBL280897 | — | — | 1 | 5.30 |
| CHEMBL21241 | GW7647 | — | 1 | 5.21 |
| CHEMBL21105 | — | — | 1 | - |
| CHEMBL21706 | — | — | 1 | - |
| CHEMBL281791 | — | — | 1 | - |
| CHEMBL279211 | — | — | 1 | - |
| CHEMBL20280 | — | — | 1 | - |
| CHEMBL281608 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20392 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL278590 | GSK-9578 | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL20125 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL20495 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL280897 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL21241 | GW7647 | EC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL21105 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL21706 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL20125 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL281791 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL279211 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL20280 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL281608 | — | EC50 | > | 10000.0 | nM | - |