Assay Detail
Binding
CHEMBL759752
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory constant against human phenylethanolamine N-methyl-transferase over-expressed in Escherichia coli
31
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Phenylethanolamine N-methyltransferase (CHEMBL4617) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Phenylethanolamine N-methyltransferase kinetics: bovine versus recombinant human enzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 5.53 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38681 | — | — | 1 | 6.55 |
| CHEMBL337144 | — | — | 1 | 6.52 |
| CHEMBL287837 | — | — | 1 | 6.52 |
| CHEMBL26717 | — | — | 1 | 6.24 |
| CHEMBL275595 | — | — | 1 | 6.18 |
| CHEMBL39493 | — | — | 1 | 6.09 |
| CHEMBL290890 | — | — | 1 | 6.02 |
| CHEMBL43183 | — | — | 1 | 6.00 |
| CHEMBL342625 | — | — | 1 | 5.96 |
| CHEMBL39928 | — | — | 1 | 5.92 |
| CHEMBL336026 | — | — | 1 | 5.82 |
| CHEMBL43021 | — | — | 1 | 5.70 |
| CHEMBL41647 | — | — | 1 | 5.68 |
| CHEMBL40081 | — | — | 1 | 5.58 |
| CHEMBL287360 | — | — | 1 | 5.46 |
| CHEMBL135908 | — | — | 1 | 5.35 |
| CHEMBL35982 | — | — | 3 | 5.00 |
| CHEMBL290010 | — | — | 1 | 5.00 |
| CHEMBL41689 | — | — | 1 | 4.89 |
| CHEMBL14346 | 1,2,3,4-TETRAHYDROISOQUINOLINE | — | 1 | 4.82 |
| CHEMBL39125 | — | — | 1 | 4.70 |
| CHEMBL288524 | — | — | 1 | 4.29 |
| CHEMBL36909 | — | — | 1 | 4.21 |
| CHEMBL41079 | — | — | 1 | - |
| CHEMBL19969 | — | — | 1 | - |
| CHEMBL288525 | — | — | 1 | - |
| CHEMBL278059 | — | — | 1 | - |
| CHEMBL39492 | — | — | 1 | - |
| CHEMBL282700 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38681 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL337144 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL287837 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL26717 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL275595 | — | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL39493 | — | Ki | = | 810.0 | nM | 6.09 |
| CHEMBL290890 | — | Ki | = | 950.0 | nM | 6.02 |
| CHEMBL43183 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL342625 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL39928 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL336026 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL43021 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL41647 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL40081 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL287360 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL135908 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL35982 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL290010 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL35982 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL41689 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL14346 | 1,2,3,4-TETRAHYDROISOQUINOLINE | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL35982 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL39125 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL288524 | — | Ki | = | 51000.0 | nM | 4.29 |
| CHEMBL36909 | — | Ki | = | 62000.0 | nM | 4.21 |
| CHEMBL19969 | — | Ki | = | 4800000.0 | nM | - |
| CHEMBL41079 | — | Ki | = | 530000.0 | nM | - |
| CHEMBL288525 | — | Ki | = | 180000.0 | nM | - |
| CHEMBL278059 | — | Ki | = | 830000.0 | nM | - |
| CHEMBL39492 | — | Ki | = | 730000.0 | nM | - |
| CHEMBL282700 | — | Ki | = | 430000.0 | nM | - |