Assay Detail
Binding
CHEMBL759755
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Inhibition of rabbit adrenal phenylethanolamine N-methyl-transferase
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Phenylethanolamine N-methyltransferase (CHEMBL4617) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibitors of phenylethanolamine N-methyltransferase and epinephrine biosynthesis. 3. Bis[tetrahydroisoquinoline]s.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.68 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL287837 | — | — | 1 | 8.00 |
| CHEMBL536247 | — | — | 1 | 7.10 |
| CHEMBL556970 | — | — | 1 | 7.00 |
| CHEMBL535579 | — | — | 1 | 6.52 |
| CHEMBL535351 | — | — | 1 | 6.00 |
| CHEMBL351394 | — | — | 1 | 5.70 |
| CHEMBL165132 | — | — | 1 | 5.70 |
| CHEMBL536702 | — | — | 1 | 5.70 |
| CHEMBL538304 | — | — | 1 | 5.70 |
| CHEMBL351378 | — | — | 1 | 5.30 |
| CHEMBL165425 | — | — | 1 | 5.16 |
| CHEMBL541610 | — | — | 1 | 5.00 |
| CHEMBL165426 | — | — | 1 | 4.30 |
| CHEMBL165252 | — | — | 1 | 4.00 |
| CHEMBL350571 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL287837 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL536247 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL556970 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL535579 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL535351 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL351394 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL165132 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL536702 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL538304 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL351378 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL165425 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL541610 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL165426 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL165252 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL350571 | — | IC50 | = | 100000.0 | nM | 4.00 |