Assay Detail
Binding
CHEMBL759756
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In vitro inhibitory potency was measured against phenylethanolamine N-methyl-transferase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Phenylethanolamine N-methyltransferase (CHEMBL4617) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibitors of phenylethanolamine N-methyltransferase and epinephrine biosynthesis. 1. Chloro-substituted 1,2,3,4-tetrahydroisoquinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.29 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL287837 | — | — | 1 | 8.00 |
| CHEMBL356439 | — | — | 1 | 7.00 |
| CHEMBL149816 | — | — | 1 | 6.70 |
| CHEMBL149023 | — | — | 1 | 6.70 |
| CHEMBL146188 | — | — | 1 | 6.70 |
| CHEMBL147230 | — | — | 1 | 4.70 |
| CHEMBL149022 | — | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL287837 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL356439 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL149816 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL149023 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL146188 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL147230 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL149022 | — | IC50 | = | 60000.0 | nM | 4.22 |