Assay Detail
Binding
CHEMBL759875
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Inhibition of Phosphodiesterase 3 from rabbit platelets
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Sildenafil (VIAGRATM), a potent and selective inhibitor of type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.25 | 4.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL444046 | — | — | 1 | 4.47 |
| CHEMBL52141 | — | — | 1 | 4.33 |
| CHEMBL53538 | LODENAFIL | -1.0 | 1 | 4.21 |
| CHEMBL431544 | — | — | 1 | 4.20 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 4.19 |
| CHEMBL52245 | — | — | 1 | 4.08 |
| CHEMBL300416 | — | — | 1 | - |
| CHEMBL52072 | — | — | 1 | - |
| CHEMBL51814 | — | — | 1 | - |
| CHEMBL910 | — | — | 1 | - |
| CHEMBL54079 | — | — | 1 | - |
| CHEMBL298535 | — | — | 1 | - |
| CHEMBL28079 | ZAPRINAST | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL444046 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL52141 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL53538 | LODENAFIL | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL431544 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL192 | SILDENAFIL | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL52245 | — | IC50 | = | 83000.0 | nM | 4.08 |
| CHEMBL300416 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL52072 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL51814 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL910 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL54079 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL298535 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL28079 | ZAPRINAST | IC50 | > | 100000.0 | nM | - |