Assay Detail
Binding
CHEMBL759986
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In vitro inhibition of porcine pancreatic phospholipase A2 evaluated by Deoxycholate-phospholipid mixed micelle assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of some substrate analogue inhibitors of phospholipase A2 and investigations by NMR and molecular modeling into the binding interactions in the enzyme-inhibitor complex.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.10 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL101972 | — | — | 1 | 5.58 |
| CHEMBL101015 | — | — | 1 | 5.46 |
| CHEMBL330205 | — | — | 1 | 4.82 |
| CHEMBL322409 | — | — | 1 | 4.52 |
| CHEMBL101890 | — | — | 1 | - |
| CHEMBL102135 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL101972 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL101015 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL330205 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL322409 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL101890 | — | IC50 | = | 300000.0 | nM | - |
| CHEMBL102135 | — | IC50 | = | 189000.0 | nM | - |