Assay Detail
Binding
CHEMBL759989
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In vitro inhibition of porcine pancreatic phospholipase A2 evaluated by monomeric substrate assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of some substrate analogue inhibitors of phospholipase A2 and investigations by NMR and molecular modeling into the binding interactions in the enzyme-inhibitor complex.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.89 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL101972 | — | — | 1 | 7.52 |
| CHEMBL101015 | — | — | 1 | 7.52 |
| CHEMBL322409 | — | — | 1 | 6.64 |
| CHEMBL102135 | — | — | 1 | 5.85 |
| CHEMBL101890 | — | — | 1 | 5.40 |
| CHEMBL4524081 | — | — | 1 | 5.35 |
| CHEMBL319067 | — | — | 1 | 5.30 |
| CHEMBL102090 | — | — | 1 | 5.22 |
| CHEMBL99161 | — | — | 1 | 5.10 |
| CHEMBL318193 | — | — | 1 | 5.00 |
| CHEMBL99160 | — | — | 1 | - |
| CHEMBL101925 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL101972 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL101015 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL322409 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL102135 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL101890 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4524081 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL319067 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL102090 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL99161 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL318193 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL99160 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL101925 | — | IC50 | = | 160000.0 | nM | - |