Assay Detail
Functional
CHEMBL760049
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Inhibition of hematin polymerization in Plasmodium falciparum
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Bisquinolines. 2. Antimalarial N,N-bis(7-chloroquinolin-4-yl)heteroalkanediamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.78 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL343320 | — | — | 1 | 5.30 |
| CHEMBL138071 | — | — | 1 | 5.10 |
| CHEMBL42527 | — | — | 1 | 4.85 |
| CHEMBL342178 | — | — | 1 | 4.80 |
| CHEMBL424284 | — | — | 1 | 4.72 |
| CHEMBL46524 | — | — | 1 | 4.70 |
| CHEMBL137686 | — | — | 1 | 4.70 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL343320 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL138071 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL42527 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL342178 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL424284 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL46524 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL137686 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 80000.0 | nM | 4.10 |