Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL760053

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro antimalarial activity against chloroquine-resistant Plasmodium falciparum W2
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Intermediate

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Bisquinolines. 2. Antimalarial N,N-bis(7-chloroquinolin-4-yl)heteroalkanediamines.
Vennerstrom JL, Ager AL, Dorn A, Andersen SL, Gerena L, Ridley RG, Milhous WK.
J Med Chem (1998) 41 : 4360 -4364
PubMed 9784111 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 7.79 8.55

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL138071 1 8.55
CHEMBL335524 1 8.27
CHEMBL342178 1 8.15
CHEMBL46524 1 8.05
CHEMBL343320 1 8.05
CHEMBL136459 1 8.00
CHEMBL424284 1 7.68
CHEMBL42527 1 7.58
CHEMBL336448 1 7.32
CHEMBL137686 1 7.05
CHEMBL76 CHLOROQUINE 4.0 1 7.00
CHEMBL139165 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL138071 IC50 = 2.8 nM 8.55
CHEMBL335524 IC50 = 5.4 nM 8.27
CHEMBL342178 IC50 = 7.0 nM 8.15
CHEMBL46524 IC50 = 8.9 nM 8.05
CHEMBL343320 IC50 = 9.0 nM 8.05
CHEMBL136459 IC50 = 9.9 nM 8.00
CHEMBL424284 IC50 = 21.0 nM 7.68
CHEMBL42527 IC50 = 26.0 nM 7.58
CHEMBL336448 IC50 = 48.0 nM 7.32
CHEMBL137686 IC50 = 89.0 nM 7.05
CHEMBL76 CHLOROQUINE IC50 = 99.0 nM 7.00
CHEMBL139165 IC50 > 1000.0 nM -