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Assay Detail

CHEMBL760064

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antimalarial activity against Plasmodium falciparum 3D7 in erythrocytes
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Expert

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Structure-activity relationships of novel anti-malarial agents. Part 3: N-(4-acylamino-3-benzoylphenyl)-4-propoxycinnamic acid amides.
Wiesner J, Kettler K, Jomaa H, Schlitzer M.
Bioorg Med Chem Lett (2002) 12 : 543 -545
PubMed 11844668 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 6.43 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL36 PYRIMETHAMINE 4.0 1 8.52
CHEMBL747 CYCLOGUANIL 2.0 1 8.12
CHEMBL76 CHLOROQUINE 4.0 1 7.70
CHEMBL38827 LUMEFANTRINE 4.0 1 7.54
CHEMBL170 QUININE 4.0 1 7.02
CHEMBL153182 1 7.00
CHEMBL153679 1 6.85
CHEMBL90812 1 6.60
CHEMBL346209 1 6.57
CHEMBL347996 1 5.92
CHEMBL150780 1 5.85
CHEMBL440729 1 5.72
CHEMBL153283 1 5.70
CHEMBL153656 1 5.57
CHEMBL359277 1 5.19
CHEMBL155159 1 4.72
CHEMBL152982 1 4.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL36 PYRIMETHAMINE IC50 = 3.0 nM 8.52
CHEMBL747 CYCLOGUANIL IC50 = 7.5 nM 8.12
CHEMBL76 CHLOROQUINE IC50 = 20.0 nM 7.70
CHEMBL38827 LUMEFANTRINE IC50 = 29.0 nM 7.54
CHEMBL170 QUININE IC50 = 96.0 nM 7.02
CHEMBL153182 IC50 = 100.0 nM 7.00
CHEMBL153679 IC50 = 140.0 nM 6.85
CHEMBL90812 IC50 = 250.0 nM 6.60
CHEMBL346209 IC50 = 270.0 nM 6.57
CHEMBL347996 IC50 = 1200.0 nM 5.92
CHEMBL150780 IC50 = 1400.0 nM 5.85
CHEMBL440729 IC50 = 1900.0 nM 5.72
CHEMBL153283 IC50 = 2000.0 nM 5.70
CHEMBL153656 IC50 = 2700.0 nM 5.57
CHEMBL359277 IC50 = 6500.0 nM 5.19
CHEMBL155159 IC50 = 19000.0 nM 4.72
CHEMBL152982 IC50 = 20000.0 nM 4.70