Assay Detail
Binding
CHEMBL760080
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of prostaglandin G/H synthase 2 expressed in human osteosarcoma 143 cells
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Cyclooxygenase-2 inhibitors. Synthesis and pharmacological activities of 5-methanesulfonamido-1-indanone derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 7.03 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL144728 | — | — | 1 | 8.00 |
| CHEMBL148153 | — | — | 1 | 8.00 |
| CHEMBL147580 | FLOSULIDE | 2.0 | 1 | 7.68 |
| CHEMBL287919 | — | — | 1 | 7.64 |
| CHEMBL144013 | — | — | 1 | 7.40 |
| CHEMBL144787 | — | — | 1 | 7.30 |
| CHEMBL344959 | — | — | 1 | 7.30 |
| CHEMBL144884 | — | — | 1 | 7.30 |
| CHEMBL342538 | — | — | 1 | 7.00 |
| CHEMBL145710 | — | — | 1 | 7.00 |
| CHEMBL358295 | — | — | 1 | 7.00 |
| CHEMBL144819 | — | — | 1 | 7.00 |
| CHEMBL289262 | — | — | 1 | 7.00 |
| CHEMBL143781 | — | — | 1 | 7.00 |
| CHEMBL144675 | — | — | 1 | 7.00 |
| CHEMBL35992 | — | — | 1 | 7.00 |
| CHEMBL146773 | — | — | 1 | 6.00 |
| CHEMBL344351 | — | — | 1 | 6.00 |
| CHEMBL144100 | — | — | 1 | 6.00 |
| CHEMBL356940 | — | — | 1 | 6.00 |
| CHEMBL144441 | — | — | 1 | - |
| CHEMBL147327 | — | — | 1 | - |
| CHEMBL424303 | — | — | 1 | - |
| CHEMBL148157 | — | — | 1 | - |
| CHEMBL145257 | — | — | 1 | - |
| CHEMBL357163 | — | — | 1 | - |
| CHEMBL356804 | — | — | 1 | - |
| CHEMBL343889 | — | — | 1 | - |
| CHEMBL356997 | — | — | 1 | - |
| CHEMBL144317 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL144728 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL148153 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL147580 | FLOSULIDE | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL287919 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL144013 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL144787 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL344959 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL144884 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL144675 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL143781 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL289262 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL35992 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL144819 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL358295 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL145710 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL342538 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL356940 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL144100 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL146773 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL344351 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL444002 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL343853 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL357918 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL343198 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL145783 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL145315 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL144441 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL147327 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL424303 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL148157 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL145257 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL357163 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL356804 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL343889 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL356997 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL144317 | — | IC50 | > | 10000.0 | nM | - |