Assay Detail
Binding
CHEMBL760088
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of prostaglandin G/H synthase 2 (COX-2).
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
1,2-Diarylcyclopentenes as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 7.66 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL108201 | — | — | 1 | 9.30 |
| CHEMBL424063 | — | — | 1 | 8.70 |
| CHEMBL111321 | — | — | 1 | 8.70 |
| CHEMBL111356 | — | — | 1 | 8.70 |
| CHEMBL111562 | — | — | 1 | 8.70 |
| CHEMBL340573 | — | — | 1 | 8.52 |
| CHEMBL127674 | — | — | 1 | 8.52 |
| CHEMBL111590 | — | — | 1 | 8.52 |
| CHEMBL109623 | — | — | 1 | 8.30 |
| CHEMBL265562 | — | — | 1 | 8.15 |
| CHEMBL111095 | — | — | 1 | 8.05 |
| CHEMBL321643 | — | — | 1 | 8.05 |
| CHEMBL111786 | — | — | 1 | 8.00 |
| CHEMBL42485 | DUP-697 | — | 1 | 8.00 |
| CHEMBL111597 | — | — | 1 | 8.00 |
| CHEMBL111427 | — | — | 1 | 7.80 |
| CHEMBL321160 | — | — | 1 | 7.77 |
| CHEMBL111787 | — | — | 1 | 7.75 |
| CHEMBL287919 | — | — | 1 | 7.70 |
| CHEMBL405623 | — | — | 1 | 7.68 |
| CHEMBL274893 | SC-57666 | — | 1 | 7.58 |
| CHEMBL322949 | — | — | 1 | 7.52 |
| CHEMBL274990 | SC-58125 | — | 1 | 7.30 |
| CHEMBL111657 | — | — | 1 | 7.29 |
| CHEMBL7162 | NS-398 | — | 1 | 7.00 |
| CHEMBL111314 | — | — | 1 | 6.92 |
| CHEMBL324863 | — | — | 1 | 6.85 |
| CHEMBL111057 | — | — | 1 | 6.82 |
| CHEMBL110846 | — | — | 1 | 6.77 |
| CHEMBL323732 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL108201 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL424063 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL111562 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL111356 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL111321 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL340573 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL127674 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL111590 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL109623 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL265562 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL111095 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL321643 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL111786 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL42485 | DUP-697 | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL111597 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL111427 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL321160 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL111787 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL287919 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL405623 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL274893 | SC-57666 | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL322949 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL274990 | SC-58125 | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL111657 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL7162 | NS-398 | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL111314 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL324863 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL111057 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL110846 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL323732 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL109030 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL336011 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL358140 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL423004 | — | IC50 | > | 100000.0 | nM | - |