Assay Detail
Functional
CHEMBL760246
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In vitro inhibitory activity against chloroquine-resistant Plasmodium falciparum NF54-R in blood
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of new fluoroquinolones and evaluation of their in vitro activity on Toxoplasma gondii and Plasmodium spp.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.33 | 4.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428 | TROVAFLOXACIN | 4.0 | 1 | 4.66 |
| CHEMBL31 | GATIFLOXACIN | 4.0 | 1 | 4.54 |
| CHEMBL315647 | — | — | 1 | 4.40 |
| CHEMBL32 | MOXIFLOXACIN | 4.0 | 1 | 4.35 |
| CHEMBL93307 | — | — | 1 | 4.04 |
| CHEMBL314302 | — | — | 1 | 4.00 |
| CHEMBL96896 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428 | TROVAFLOXACIN | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL31 | GATIFLOXACIN | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL315647 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL32 | MOXIFLOXACIN | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL93307 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL314302 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL96896 | — | IC50 | = | 105000.0 | nM | - |