Assay Detail
Functional
CHEMBL760274
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In vitro antiparasitic activity against chloroquine-sensitive Plasmodium falciparum Haiti 135
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Parallel solution-phase synthesis of conformationally restricted congeners of pentamidine and evaluation of their antiplasmodial activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.84 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL537672 | — | — | 1 | 8.52 |
| CHEMBL540380 | — | — | 1 | 8.52 |
| CHEMBL539512 | — | — | 1 | 8.52 |
| CHEMBL539613 | — | — | 1 | 8.52 |
| CHEMBL539612 | — | — | 1 | 8.40 |
| CHEMBL3216192 | — | — | 1 | 8.30 |
| CHEMBL538481 | — | — | 1 | 8.22 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 8.22 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 7.82 |
| CHEMBL541808 | — | — | 1 | 7.40 |
| CHEMBL558206 | — | — | 1 | 7.00 |
| CHEMBL540527 | — | — | 1 | 6.82 |
| CHEMBL3215536 | — | — | 1 | 5.70 |
| CHEMBL328338 | — | — | 1 | - |
| CHEMBL90753 | — | — | 1 | - |
| CHEMBL44144 | — | — | 1 | - |
| CHEMBL421358 | — | — | 1 | - |
| CHEMBL290691 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL537672 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL540380 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL539512 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL539613 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL539612 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3216192 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL538481 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL541808 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL558206 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL540527 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3215536 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL328338 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL90753 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL44144 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL421358 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL290691 | — | IC50 | > | 500.0 | nM | - |