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Assay Detail

CHEMBL760279

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Functional
In vitro antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Indochina I
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Expert

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Structure-activity relationships for antiplasmodial activity among 7-substituted 4-aminoquinolines.
De D, Krogstad FM, Byers LD, Krogstad DJ.
J Med Chem (1998) 41 : 4918 -4926
PubMed 9836608 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 27 7.39 8.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL356119 1 8.40
CHEMBL317364 1 8.30
CHEMBL332186 1 8.22
CHEMBL148399 1 8.22
CHEMBL144037 1 8.22
CHEMBL118741 1 8.15
CHEMBL145445 1 8.15
CHEMBL139984 1 8.00
CHEMBL144506 1 7.92
CHEMBL148021 1 7.75
CHEMBL145444 1 7.46
CHEMBL116204 1 7.39
CHEMBL144539 1 7.35
CHEMBL144592 1 7.30
CHEMBL356292 1 7.29
CHEMBL147802 1 7.25
CHEMBL146333 1 7.24
CHEMBL118743 1 7.22
CHEMBL144670 1 7.22
CHEMBL344599 1 7.05
CHEMBL76 CHLOROQUINE 4.0 1 7.02
CHEMBL144763 1 6.92
CHEMBL119049 1 6.81
CHEMBL434116 1 6.75
CHEMBL343433 1 6.30
CHEMBL147639 1 6.05
CHEMBL144308 1 5.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL356119 IC50 = 4.0 nM 8.40
CHEMBL317364 IC50 = 5.0 nM 8.30
CHEMBL332186 IC50 = 6.0 nM 8.22
CHEMBL148399 IC50 = 6.0 nM 8.22
CHEMBL144037 IC50 = 6.0 nM 8.22
CHEMBL118741 IC50 = 7.0 nM 8.15
CHEMBL145445 IC50 = 7.0 nM 8.15
CHEMBL139984 IC50 = 10.0 nM 8.00
CHEMBL144506 IC50 = 12.0 nM 7.92
CHEMBL148021 IC50 = 18.0 nM 7.75
CHEMBL145444 IC50 = 35.0 nM 7.46
CHEMBL116204 IC50 = 41.0 nM 7.39
CHEMBL144539 IC50 = 45.0 nM 7.35
CHEMBL144592 IC50 = 50.0 nM 7.30
CHEMBL356292 IC50 = 51.0 nM 7.29
CHEMBL147802 IC50 = 56.0 nM 7.25
CHEMBL146333 IC50 = 58.0 nM 7.24
CHEMBL118743 IC50 = 60.0 nM 7.22
CHEMBL144670 IC50 = 60.0 nM 7.22
CHEMBL344599 IC50 = 90.0 nM 7.05
CHEMBL76 CHLOROQUINE IC50 = 95.0 nM 7.02
CHEMBL144763 IC50 = 120.0 nM 6.92
CHEMBL119049 IC50 = 155.0 nM 6.81
CHEMBL434116 IC50 = 180.0 nM 6.75
CHEMBL343433 IC50 = 500.0 nM 6.30
CHEMBL147639 IC50 = 900.0 nM 6.05
CHEMBL144308 IC50 = 3000.0 nM 5.52