Assay Detail
Binding
CHEMBL760293
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Inhibition of Phoshoinositol 3 kinase from MCF-7 breast cancer cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.76 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL366754 | — | — | 1 | 5.52 |
| CHEMBL263287 | — | — | 1 | 5.30 |
| CHEMBL366755 | — | — | 1 | 4.87 |
| CHEMBL367315 | — | — | 1 | 4.85 |
| CHEMBL173055 | — | — | 1 | 4.55 |
| CHEMBL422731 | — | — | 1 | 4.16 |
| CHEMBL424579 | — | — | 1 | 4.07 |
| CHEMBL262054 | — | — | 1 | - |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | - |
| CHEMBL355195 | — | — | 1 | - |
| CHEMBL173928 | — | — | 1 | - |
| CHEMBL366637 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL366754 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL263287 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL366755 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL367315 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL173055 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL422731 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL424579 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL262054 | — | IC50 | = | 310000.0 | nM | - |
| CHEMBL109480 | TANESPIMYCIN | IC50 | > | 500000.0 | nM | - |
| CHEMBL355195 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL173928 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL366637 | — | IC50 | = | 200000.0 | nM | - |