Assay Detail
Functional
CHEMBL760331
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Compound was evaluated for its antagonism in CHO cells expressing the human receptor (hPI)
15
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Quinolones as gonadotropin releasing hormone (GnRH) antagonists: simultaneous optimization of the C(3)-aryl and C(6)-substituents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.72 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48192 | — | — | 1 | 8.66 |
| CHEMBL45883 | — | — | 1 | 8.30 |
| CHEMBL296321 | — | — | 2 | 8.30 |
| CHEMBL49230 | — | — | 1 | 8.19 |
| CHEMBL48165 | — | — | 1 | 8.15 |
| CHEMBL45784 | — | — | 1 | 8.11 |
| CHEMBL46177 | — | — | 1 | 8.07 |
| CHEMBL50283 | — | — | 1 | 8.05 |
| CHEMBL48674 | — | — | 1 | 7.80 |
| CHEMBL46312 | — | — | 1 | 7.64 |
| CHEMBL48249 | — | — | 1 | 7.28 |
| CHEMBL49293 | — | — | 1 | 6.65 |
| CHEMBL45501 | — | — | 1 | 6.64 |
| CHEMBL417189 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48192 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL45883 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL296321 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL49230 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL48165 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL45784 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL46177 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL50283 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL296321 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL48674 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL46312 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL48249 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL49293 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL45501 | — | IC50 | = | 227.0 | nM | 6.64 |
| CHEMBL417189 | — | IC50 | = | 897.0 | nM | 6.05 |