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Assay Detail

CHEMBL760446

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Compound was evaluated for anti-platelet activating factor potency
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Platelet-activating factor receptor (CHEMBL250)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

A 3D-QSAR study on ginkgolides and their analogues with comparative molecular field analysis.
Chen JZ, Hu LH, Jiang HL, Gu JD, Zhu WL, Chen ZL, Chen KX, Ji RY.
Bioorg Med Chem Lett (1998) 8 : 1291 -1296
PubMed 9871752 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 4 7.26 7.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2304168 1 7.54
CHEMBL2304167 1 7.39
CHEMBL2304166 1 7.23
CHEMBL514432 GINKOLIDE B 1 6.89

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2304168 IC50 = 28.9 nM 7.54
CHEMBL2304167 IC50 = 40.4 nM 7.39
CHEMBL2304166 IC50 = 58.8 nM 7.23
CHEMBL514432 GINKOLIDE B IC50 = 128.0 nM 6.89