Assay Detail
Binding
CHEMBL760584
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Tested for its ability to inhibit the hydrolysis of cAMP by human monocyte cytosol phosphodiesterase
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Biarylcarboxamide inhibitors of phosphodiesterase IV and tumor necrosis factor-
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.81 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL352153 | — | — | 1 | 6.47 |
| CHEMBL511115 | CILOMILAST | 3.0 | 1 | 6.44 |
| CHEMBL166320 | — | — | 1 | 5.97 |
| CHEMBL162663 | — | — | 1 | 5.44 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 5.32 |
| CHEMBL165158 | — | — | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL352153 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL511115 | CILOMILAST | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL166320 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL162663 | — | IC50 | = | 3610.0 | nM | 5.44 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 4750.0 | nM | 5.32 |
| CHEMBL165158 | — | IC50 | = | 5910.0 | nM | 5.23 |