Assay Detail
Binding
CHEMBL760585
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of phosphodiesterase (PDE V).
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Imidazotriazinone inhibitors of the Ca2+-calmodulin sensitive phosphodiesterase (PDE I)
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.03 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL28079 | ZAPRINAST | 2.0 | 1 | 6.52 |
| CHEMBL173510 | — | — | 1 | 5.77 |
| CHEMBL173317 | — | — | 1 | 5.54 |
| CHEMBL367927 | — | — | 1 | 5.51 |
| CHEMBL366938 | — | — | 1 | 5.41 |
| CHEMBL426946 | — | — | 1 | 5.01 |
| CHEMBL174270 | — | — | 1 | 4.92 |
| CHEMBL176346 | — | — | 1 | 4.83 |
| CHEMBL354843 | — | — | 1 | 4.75 |
| CHEMBL355748 | — | — | 1 | 4.74 |
| CHEMBL366999 | — | — | 1 | 4.71 |
| CHEMBL366491 | — | — | 1 | 4.67 |
| CHEMBL368198 | — | — | 1 | 4.64 |
| CHEMBL368322 | — | — | 1 | 4.25 |
| CHEMBL369431 | — | — | 1 | 4.18 |
| CHEMBL369172 | — | — | 1 | - |
| CHEMBL367221 | — | — | 1 | - |
| CHEMBL173275 | — | — | 1 | - |
| CHEMBL369830 | — | — | 1 | - |
| CHEMBL170449 | — | — | 1 | - |
| CHEMBL426937 | — | — | 1 | - |
| CHEMBL170228 | — | — | 1 | - |
| CHEMBL440593 | CI-930 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL28079 | ZAPRINAST | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL173510 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL173317 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL367927 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL366938 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL426946 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL174270 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL176346 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL354843 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL355748 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL366999 | — | IC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL366491 | — | IC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL368198 | — | IC50 | = | 22700.0 | nM | 4.64 |
| CHEMBL368322 | — | IC50 | = | 56100.0 | nM | 4.25 |
| CHEMBL369431 | — | IC50 | = | 66700.0 | nM | 4.18 |
| CHEMBL369172 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL367221 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL173275 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL369830 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL170449 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL426937 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL170228 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL440593 | CI-930 | IC50 | > | 10000.0 | nM | - |