Assay Detail
Binding
CHEMBL760593
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Inhibitory activity against Phosphodiesterase type IV (PDE4) obtained from guinea-pig macrophage was evaluated
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
The synthesis and biological evaluation of a novel series of indole PDE4 inhibitors I.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.25 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54988 | — | — | 1 | 8.49 |
| CHEMBL293775 | — | — | 1 | 8.30 |
| CHEMBL55046 | — | — | 1 | 8.28 |
| CHEMBL53710 | — | — | 1 | 7.92 |
| CHEMBL55867 | — | — | 1 | 7.82 |
| CHEMBL301201 | — | — | 1 | 7.75 |
| CHEMBL54361 | — | — | 1 | 7.60 |
| CHEMBL55203 | — | — | 1 | 7.60 |
| CHEMBL301448 | — | — | 1 | 7.38 |
| CHEMBL52712 | — | — | 1 | 7.35 |
| CHEMBL54590 | — | — | 1 | 7.34 |
| CHEMBL300395 | — | — | 1 | 7.28 |
| CHEMBL53559 | — | — | 1 | 7.22 |
| CHEMBL429356 | — | — | 1 | 7.16 |
| CHEMBL292925 | — | — | 1 | 7.10 |
| CHEMBL299332 | — | — | 1 | 7.00 |
| CHEMBL417930 | — | — | 1 | 6.73 |
| CHEMBL445354 | — | — | 1 | 6.70 |
| CHEMBL54767 | — | — | 1 | 6.66 |
| CHEMBL56406 | — | — | 1 | 6.52 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 6.50 |
| CHEMBL294831 | — | — | 1 | 6.42 |
| CHEMBL53373 | — | — | 1 | 5.54 |
| CHEMBL300129 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54988 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL293775 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL55046 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL53710 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL55867 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL301201 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL54361 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL55203 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL301448 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL52712 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL54590 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL300395 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL53559 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL429356 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL292925 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL299332 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL417930 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL445354 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL54767 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL56406 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL294831 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL53373 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL300129 | — | IC50 | > | 10000.0 | nM | - |