Assay Detail
Binding
CHEMBL760598
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Inhibition of PDE4 enzyme from U937 cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Thalidomide analogs and PDE4 inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.01 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL313439 | — | — | 1 | 6.89 |
| CHEMBL88475 | — | — | 1 | 6.64 |
| CHEMBL315529 | — | — | 1 | 6.46 |
| CHEMBL90349 | — | — | 1 | 6.13 |
| CHEMBL88153 | CDC-801 | 2.0 | 1 | 5.96 |
| CHEMBL314759 | — | — | 1 | 5.89 |
| CHEMBL90345 | — | — | 1 | 5.77 |
| CHEMBL419135 | — | — | 1 | 5.70 |
| CHEMBL88935 | — | — | 1 | 5.60 |
| CHEMBL89890 | — | — | 1 | 5.03 |
| CHEMBL468 | THALIDOMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL313439 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL88475 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL315529 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL90349 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL88153 | CDC-801 | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL314759 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL90345 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL419135 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL88935 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL89890 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL468 | THALIDOMIDE | IC50 | > | 500000.0 | nM | - |