Assay Detail
Functional
CHEMBL760604
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Maximal reporter activity against human Peroxisome proliferator activated receptor alpha Gal4 chimeric in transiently transfected CV-1 cells by functional assay.
6
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CV-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological activity of L-tyrosine-based PPARgamma agonists with reduced molecular weight.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.73 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107367 | FARGLITAZAR | 2.0 | 1 | 6.35 |
| CHEMBL321634 | — | — | 1 | 6.08 |
| CHEMBL104850 | — | — | 2 | 5.89 |
| CHEMBL106666 | GW7845 | — | 1 | 5.46 |
| CHEMBL104246 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107367 | FARGLITAZAR | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL321634 | — | EC50 | = | 830.0 | nM | 6.08 |
| CHEMBL104850 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL106666 | GW7845 | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL104850 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL104246 | — | EC50 | = | 6900.0 | nM | 5.16 |