Assay Detail
Functional
CHEMBL760605
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cotransfection activity against human Peroxisome proliferator activated receptor alpha
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of a potent and selective triazolone-based peroxisome proliferator-activated receptor alpha agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 7.09 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL148639 | — | — | 1 | 8.70 |
| CHEMBL344282 | — | — | 1 | 8.40 |
| CHEMBL149676 | — | — | 1 | 8.22 |
| CHEMBL345721 | — | — | 1 | 7.51 |
| CHEMBL424133 | LY-518674 | 2.0 | 1 | 7.38 |
| CHEMBL149438 | — | — | 1 | 7.25 |
| CHEMBL148774 | — | — | 1 | 7.06 |
| CHEMBL356170 | — | — | 1 | 6.66 |
| CHEMBL359053 | — | — | 1 | 5.66 |
| CHEMBL147086 | — | — | 1 | 5.57 |
| CHEMBL148856 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL148639 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL344282 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL149676 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL345721 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL424133 | LY-518674 | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL149438 | — | EC50 | = | 56.0 | nM | 7.25 |
| CHEMBL148774 | — | EC50 | = | 88.0 | nM | 7.06 |
| CHEMBL356170 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL359053 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL147086 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL148856 | — | EC50 | = | 2800.0 | nM | 5.55 |