Assay Detail
Binding
CHEMBL760607
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In vitro activation of human peroxisome proliferator activated receptor alpha
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of novel PPARalpha/gamma/delta triple activators using a known PPARalpha/gamma dual activator as structural template.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 5.84 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL87307 | — | — | 1 | 6.52 |
| CHEMBL87928 | — | — | 1 | 6.52 |
| CHEMBL86658 | — | — | 1 | 6.44 |
| CHEMBL89996 | — | — | 1 | 6.40 |
| CHEMBL421729 | — | — | 1 | 6.16 |
| CHEMBL87380 | — | — | 1 | 6.16 |
| CHEMBL420973 | — | — | 1 | 6.05 |
| CHEMBL328455 | — | — | 1 | 5.96 |
| CHEMBL89152 | — | — | 1 | 5.96 |
| CHEMBL86817 | — | — | 1 | 5.70 |
| CHEMBL328099 | — | — | 1 | 5.66 |
| CHEMBL86688 | — | — | 1 | 5.66 |
| CHEMBL315048 | — | — | 1 | 5.50 |
| CHEMBL672 | FENOFIBRATE | 4.0 | 1 | 5.49 |
| CHEMBL24038 | RAGAGLITAZAR | 2.0 | 1 | 5.49 |
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | 5.39 |
| CHEMBL86657 | — | — | 1 | 5.35 |
| CHEMBL327481 | — | — | 1 | 5.28 |
| CHEMBL314483 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL87307 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL87928 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL86658 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL89996 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL421729 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL87380 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL420973 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL328455 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL89152 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL86817 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL328099 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL86688 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL315048 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL672 | FENOFIBRATE | EC50 | = | 3210.0 | nM | 5.49 |
| CHEMBL24038 | RAGAGLITAZAR | EC50 | = | 3210.0 | nM | 5.49 |
| CHEMBL121 | ROSIGLITAZONE | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL86657 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL327481 | — | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL314483 | — | EC50 | = | 6400.0 | nM | 5.19 |