Assay Detail
Binding
CHEMBL760611
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro transcriptional activation in CV-1 cells expressing human Gal4-PPAR alpha ligand binding domain
13
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CV-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 7.90 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL21706 | — | — | 1 | 9.00 |
| CHEMBL20392 | — | — | 1 | 8.30 |
| CHEMBL21241 | GW7647 | — | 1 | 8.22 |
| CHEMBL20495 | — | — | 1 | 8.22 |
| CHEMBL280897 | — | — | 1 | 8.10 |
| CHEMBL279211 | — | — | 1 | 8.05 |
| CHEMBL20280 | — | — | 1 | 8.05 |
| CHEMBL20125 | — | — | 2 | 7.77 |
| CHEMBL281791 | — | — | 1 | 7.70 |
| CHEMBL281608 | — | — | 1 | 7.30 |
| CHEMBL278590 | GSK-9578 | — | 1 | 7.30 |
| CHEMBL21105 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL21706 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL20392 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL21241 | GW7647 | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL20495 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL280897 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL279211 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL20280 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL20125 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL281791 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL20125 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL281608 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL278590 | GSK-9578 | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL21105 | — | EC50 | = | 100.0 | nM | 7.00 |