Assay Detail
Functional
CHEMBL760653
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In vitro antimalarial activity against Plasmodium falciparum in 20 mM FeCl3
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Mechanism-based development of new antimalarials: synthesis of derivatives of artemisinin attached to iron chelators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.89 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75471 | — | — | 1 | 8.47 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.27 |
| CHEMBL305899 | — | — | 1 | 8.04 |
| CHEMBL307153 | — | — | 1 | 7.78 |
| CHEMBL307138 | — | — | 1 | 7.48 |
| CHEMBL77491 | — | — | 1 | 7.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75471 | — | IC50 | = | 3.38 | nM | 8.47 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 5.41 | nM | 8.27 |
| CHEMBL305899 | — | IC50 | = | 9.21 | nM | 8.04 |
| CHEMBL307153 | — | IC50 | = | 16.8 | nM | 7.78 |
| CHEMBL307138 | — | IC50 | = | 32.91 | nM | 7.48 |
| CHEMBL77491 | — | IC50 | = | 48.71 | nM | 7.31 |