Assay Detail
Functional
CHEMBL760656
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In vivo antimalarial activity against Plasmodium falciparum
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
New neplanocin analogues. 12. Alternative synthesis and antimalarial effect of (6'R)-6'-C-methylneplanocin A, a potent AdoHcy hydrolase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.15 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.75 |
| CHEMBL327105 | — | — | 1 | 7.00 |
| CHEMBL8771 | NEOPLANOCIN A | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL327105 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL8771 | NEOPLANOCIN A | IC50 | = | 200.0 | nM | 6.70 |