Assay Detail
Functional
CHEMBL760686
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Relative resistance was measured against human paclitaxel-resistant cell lines
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | ptx-10/22 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of 2-acyl analogues of paclitaxel (Taxol).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 9.23 | 9.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL332915 | — | — | 1 | 9.57 |
| CHEMBL122857 | — | — | 1 | 9.57 |
| CHEMBL331608 | — | — | 1 | 9.54 |
| CHEMBL412803 | — | — | 1 | 9.46 |
| CHEMBL333538 | — | — | 1 | 9.43 |
| CHEMBL415835 | — | — | 1 | 9.40 |
| CHEMBL441085 | — | — | 1 | 9.38 |
| CHEMBL339660 | — | — | 1 | 9.32 |
| CHEMBL333647 | — | — | 1 | 9.32 |
| CHEMBL332080 | — | — | 1 | 9.28 |
| CHEMBL334075 | — | — | 1 | 9.24 |
| CHEMBL123018 | — | — | 1 | 9.24 |
| CHEMBL122150 | — | — | 1 | 9.24 |
| CHEMBL333526 | — | — | 1 | 9.21 |
| CHEMBL333226 | — | — | 1 | 9.17 |
| CHEMBL332916 | — | — | 1 | 9.15 |
| CHEMBL410880 | — | — | 1 | 9.12 |
| CHEMBL337989 | — | — | 1 | 9.12 |
| CHEMBL334077 | — | — | 1 | 9.02 |
| CHEMBL123431 | — | — | 1 | 9.02 |
| CHEMBL339937 | — | — | 1 | 8.96 |
| CHEMBL334112 | — | — | 1 | 8.89 |
| CHEMBL333031 | — | — | 1 | 8.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL332915 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL122857 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL331608 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL412803 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL333538 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL415835 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL441085 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL339660 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL333647 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL332080 | — | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL334075 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL123018 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL122150 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL333526 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL333226 | — | IC50 | = | 0.67 | nM | 9.17 |
| CHEMBL332916 | — | IC50 | = | 0.71 | nM | 9.15 |
| CHEMBL410880 | — | IC50 | = | 0.76 | nM | 9.12 |
| CHEMBL337989 | — | IC50 | = | 0.76 | nM | 9.12 |
| CHEMBL334077 | — | IC50 | = | 0.96 | nM | 9.02 |
| CHEMBL123431 | — | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL339937 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL334112 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL333031 | — | IC50 | = | 2.9 | nM | 8.54 |