Assay Detail
Binding
CHEMBL760742
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Inhibitory concentration against recombinant HIV-1 protease expressed in Escherichia coli was tested by HPLC based assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Potent HIV protease inhibitors containing a novel (hydroxyethyl)amide isostere.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.60 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71334 | — | — | 1 | 8.72 |
| CHEMBL66460 | — | — | 1 | 8.66 |
| CHEMBL66399 | — | — | 1 | 8.66 |
| CHEMBL304086 | — | — | 1 | 8.60 |
| CHEMBL1790508 | — | — | 1 | 8.52 |
| CHEMBL1790509 | — | — | 1 | 8.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71334 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL66460 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL66399 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL304086 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL1790508 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1790509 | — | IC50 | = | 3.6 | nM | 8.44 |