Assay Detail
Binding
CHEMBL760758
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Inhibition activity against human monocyte derived PDE4 catalytic activity (LPDE4)
19
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
1,4-Cyclohexanecarboxylates: potent and selective inhibitors of phosophodiesterase 4 for the treatment of asthma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.39 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL352628 | — | — | 1 | 7.36 |
| CHEMBL354447 | — | — | 1 | 7.28 |
| CHEMBL169537 | — | — | 1 | 7.10 |
| CHEMBL511115 | CILOMILAST | 3.0 | 4 | 7.02 |
| CHEMBL167486 | — | — | 1 | 6.92 |
| CHEMBL167166 | — | — | 1 | 6.71 |
| CHEMBL430893 | (-)-ROLIPRAM | — | 1 | 6.52 |
| CHEMBL166529 | — | — | 1 | 6.50 |
| CHEMBL169834 | — | — | 1 | 6.47 |
| CHEMBL169746 | — | — | 1 | 6.30 |
| CHEMBL352857 | — | — | 1 | 6.13 |
| CHEMBL325795 | S-ROLIPRAM | — | 1 | 5.96 |
| CHEMBL354656 | — | — | 1 | 5.93 |
| CHEMBL167258 | — | — | 1 | 5.92 |
| CHEMBL167638 | — | — | 1 | 5.92 |
| CHEMBL168989 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL352628 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL354447 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL169537 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL511115 | CILOMILAST | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL167486 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL167166 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL430893 | (-)-ROLIPRAM | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL166529 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL169834 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL169746 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL511115 | CILOMILAST | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL352857 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL511115 | CILOMILAST | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL325795 | S-ROLIPRAM | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL354656 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL167638 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL167258 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL168989 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL511115 | CILOMILAST | IC50 | = | 3410.0 | nM | 5.47 |