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Assay Detail

CHEMBL760824

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of phosphodiesterase 2 at 100 uM
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 9 — Direct single protein target
Curated By Expert

Target

cGMP-dependent 3',5'-cyclic phosphodiesterase (CHEMBL3477)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Inhibition of cyclic nucleotide phosphodiesterase by derivatives of 1,3-bis(cyclopropylmethyl)xanthine.
Buckle DR, Arch JR, Connolly BJ, Fenwick AE, Foster KA, Murray KJ, Readshaw SA, Smallridge M, Smith DG.
J Med Chem (1994) 37 : 476 -485
PubMed 8120866 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.27 5.27

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL357428 1 5.27

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL357428 IC50 = 5400.0 nM 5.27