Assay Detail
Binding
CHEMBL760828
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Inhibitory activity against Phosphodiesterase 5 (PDE5) was evaluated
29
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Furoyl and benzofuroyl pyrroloquinolones as potent and selective PDE5 inhibitors for treatment of erectile dysfunction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 8.98 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139785 | — | — | 1 | 9.82 |
| CHEMBL334903 | — | — | 2 | 9.70 |
| CHEMBL342159 | — | — | 1 | 9.62 |
| CHEMBL138949 | — | — | 1 | 9.51 |
| CHEMBL336003 | — | — | 1 | 9.46 |
| CHEMBL343596 | — | — | 1 | 9.33 |
| CHEMBL423180 | — | — | 1 | 9.28 |
| CHEMBL424280 | — | — | 1 | 9.21 |
| CHEMBL344431 | — | — | 1 | 9.21 |
| CHEMBL342922 | — | — | 1 | 9.15 |
| CHEMBL335784 | — | — | 1 | 9.14 |
| CHEMBL342404 | — | — | 1 | 9.12 |
| CHEMBL344152 | — | — | 1 | 9.01 |
| CHEMBL142030 | — | — | 1 | 9.00 |
| CHEMBL136521 | — | — | 1 | 9.00 |
| CHEMBL422100 | — | — | 1 | 8.89 |
| CHEMBL138511 | — | — | 1 | 8.77 |
| CHEMBL136498 | — | — | 1 | 8.76 |
| CHEMBL342197 | — | — | 1 | 8.75 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 8.72 |
| CHEMBL423177 | — | — | 1 | 8.68 |
| CHEMBL336921 | — | — | 1 | 8.68 |
| CHEMBL344366 | — | — | 1 | 8.60 |
| CHEMBL337782 | — | — | 1 | 8.58 |
| CHEMBL337560 | — | — | 1 | 8.57 |
| CHEMBL138799 | — | — | 1 | 8.48 |
| CHEMBL335090 | — | — | 1 | 8.43 |
| CHEMBL337804 | — | — | 1 | 8.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139785 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL334903 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL342159 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL138949 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL336003 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL343596 | — | Ki | = | 0.47 | nM | 9.33 |
| CHEMBL423180 | — | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL424280 | — | Ki | = | 0.61 | nM | 9.21 |
| CHEMBL344431 | — | Ki | = | 0.61 | nM | 9.21 |
| CHEMBL342922 | — | Ki | = | 0.71 | nM | 9.15 |
| CHEMBL335784 | — | Ki | = | 0.73 | nM | 9.14 |
| CHEMBL342404 | — | Ki | = | 0.76 | nM | 9.12 |
| CHEMBL344152 | — | Ki | = | 0.98 | nM | 9.01 |
| CHEMBL142030 | — | Ki | = | 0.99 | nM | 9.00 |
| CHEMBL136521 | — | Ki | = | 1.01 | nM | 9.00 |
| CHEMBL422100 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL138511 | — | Ki | = | 1.71 | nM | 8.77 |
| CHEMBL136498 | — | Ki | = | 1.74 | nM | 8.76 |
| CHEMBL342197 | — | Ki | = | 1.78 | nM | 8.75 |
| CHEMBL334903 | — | Ki | = | 1.82 | nM | 8.74 |
| CHEMBL192 | SILDENAFIL | Ki | = | 1.91 | nM | 8.72 |
| CHEMBL423177 | — | Ki | = | 2.07 | nM | 8.68 |
| CHEMBL336921 | — | Ki | = | 2.09 | nM | 8.68 |
| CHEMBL344366 | — | Ki | = | 2.49 | nM | 8.60 |
| CHEMBL337782 | — | Ki | = | 2.64 | nM | 8.58 |
| CHEMBL337560 | — | Ki | = | 2.71 | nM | 8.57 |
| CHEMBL138799 | — | Ki | = | 3.32 | nM | 8.48 |
| CHEMBL335090 | — | Ki | = | 3.74 | nM | 8.43 |
| CHEMBL337804 | — | Ki | = | 4.66 | nM | 8.33 |