Assay Detail
Functional
CHEMBL760856
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonistic activity for human Peroxisome proliferator activated receptor gamma
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological and structural characterization of the dual-acting peroxisome proliferator-activated receptor alpha/gamma agonist ragaglitazar.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.07 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL24038 | RAGAGLITAZAR | 2.0 | 1 | 6.22 |
| CHEMBL24458 | — | — | 1 | 6.10 |
| CHEMBL25259 | — | — | 1 | 6.06 |
| CHEMBL282686 | TESAGLITAZAR | 3.0 | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL24038 | RAGAGLITAZAR | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL24458 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL25259 | — | EC50 | = | 880.0 | nM | 6.06 |
| CHEMBL282686 | TESAGLITAZAR | EC50 | = | 1300.0 | nM | 5.89 |