Assay Detail
Binding
CHEMBL760888
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Inhibition of Progesterone 21-hydroxylase cytochrome P450 21
4
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Stereoisomers of ketoconazole: preparation and biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.13 | 5.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL319160 | — | — | 1 | 5.35 |
| CHEMBL328863 | — | — | 1 | 5.18 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 2 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL319160 | — | IC50 | = | 4460.0 | nM | 5.35 |
| CHEMBL328863 | — | IC50 | = | 6570.0 | nM | 5.18 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 9010.0 | nM | 5.04 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 11200.0 | nM | 4.95 |