Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL760893

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Tested for inhibition of plasminogen activator urokinase (microPa)
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Urokinase-type plasminogen activator (CHEMBL3286)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

3-Amidinophenylalanine-based inhibitors of urokinase.
Stürzebecher J, Vieweg H, Steinmetzer T, Schweinitz A, Stubbs MT, Renatus M, Wikström P.
Bioorg Med Chem Lett (1999) 9 : 3147 -3152
PubMed 10560742 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 25 5.05 6.07

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL326866 1 6.07
CHEMBL108468 1 6.02
CHEMBL106395 1 5.89
CHEMBL318773 1 5.89
CHEMBL106079 1 5.70
CHEMBL108058 1 5.60
CHEMBL322830 1 5.46
CHEMBL107203 1 5.36
CHEMBL108354 1 5.32
CHEMBL324188 1 5.29
CHEMBL106412 1 5.27
CHEMBL320285 1 5.11
CHEMBL110628 1 4.92
CHEMBL106035 1 4.92
CHEMBL320257 1 4.77
CHEMBL318304 1 4.72
CHEMBL107140 1 4.72
CHEMBL107256 1 4.72
CHEMBL107592 1 4.55
CHEMBL105875 1 4.48
CHEMBL104241 1 4.42
CHEMBL319868 1 4.32
CHEMBL323452 1 4.28
CHEMBL105935 1 4.28
CHEMBL107210 1 4.24

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL326866 Ki = 860.0 nM 6.07
CHEMBL108468 Ki = 960.0 nM 6.02
CHEMBL106395 Ki = 1300.0 nM 5.89
CHEMBL318773 Ki = 1300.0 nM 5.89
CHEMBL106079 Ki = 2000.0 nM 5.70
CHEMBL108058 Ki = 2500.0 nM 5.60
CHEMBL322830 Ki = 3500.0 nM 5.46
CHEMBL107203 Ki = 4400.0 nM 5.36
CHEMBL108354 Ki = 4800.0 nM 5.32
CHEMBL324188 Ki = 5100.0 nM 5.29
CHEMBL106412 Ki = 5400.0 nM 5.27
CHEMBL320285 Ki = 7800.0 nM 5.11
CHEMBL110628 Ki = 12000.0 nM 4.92
CHEMBL106035 Ki = 12000.0 nM 4.92
CHEMBL320257 Ki = 17000.0 nM 4.77
CHEMBL318304 Ki = 19000.0 nM 4.72
CHEMBL107140 Ki = 19000.0 nM 4.72
CHEMBL107256 Ki = 19000.0 nM 4.72
CHEMBL107592 Ki = 28000.0 nM 4.55
CHEMBL105875 Ki = 33000.0 nM 4.48
CHEMBL104241 Ki = 38000.0 nM 4.42
CHEMBL319868 Ki = 48000.0 nM 4.32
CHEMBL323452 Ki = 52000.0 nM 4.28
CHEMBL105935 Ki = 52000.0 nM 4.28
CHEMBL107210 Ki = 58000.0 nM 4.24