Assay Detail
Binding
CHEMBL760933
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Inhibition of Phosphodiesterase 1 from rat liver
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Publication
Sildenafil (VIAGRATM), a potent and selective inhibitor of type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.12 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL444046 | — | — | 1 | 6.96 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 6.58 |
| CHEMBL910 | — | — | 1 | 6.41 |
| CHEMBL53538 | LODENAFIL | -1.0 | 1 | 6.34 |
| CHEMBL54079 | — | — | 1 | 6.10 |
| CHEMBL298535 | — | — | 1 | 6.07 |
| CHEMBL51814 | — | — | 1 | 5.48 |
| CHEMBL28079 | ZAPRINAST | 2.0 | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL444046 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL192 | SILDENAFIL | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL910 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL53538 | LODENAFIL | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL54079 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL298535 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL51814 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL28079 | ZAPRINAST | IC50 | = | 9400.0 | nM | 5.03 |