Assay Detail
Binding
CHEMBL760952
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Inhibition of recombinant human secretory phospholipase A2 (sPLA2), chromogenic screening assay.
64
Total Activities
64
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potent inhibitors of secretory phospholipase A2: synthesis and inhibitory activities of indolizine and indene derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 64 | 7.31 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL121609 | — | — | 1 | 8.30 |
| CHEMBL332993 | — | — | 1 | 8.22 |
| CHEMBL331755 | — | — | 1 | 8.22 |
| CHEMBL121245 | — | — | 1 | 8.22 |
| CHEMBL121627 | — | — | 1 | 8.10 |
| CHEMBL121617 | — | — | 1 | 8.10 |
| CHEMBL332547 | — | — | 1 | 8.10 |
| CHEMBL121645 | — | — | 1 | 8.05 |
| CHEMBL332957 | — | — | 1 | 8.05 |
| CHEMBL120112 | — | — | 1 | 8.05 |
| CHEMBL414424 | — | — | 1 | 8.00 |
| CHEMBL123182 | — | — | 1 | 8.00 |
| CHEMBL123774 | — | — | 1 | 7.96 |
| CHEMBL122736 | — | — | 1 | 7.96 |
| CHEMBL121030 | — | — | 1 | 7.89 |
| CHEMBL123384 | — | — | 1 | 7.89 |
| CHEMBL330987 | — | — | 1 | 7.85 |
| CHEMBL121481 | — | — | 1 | 7.85 |
| CHEMBL420169 | — | — | 1 | 7.82 |
| CHEMBL121199 | — | — | 1 | 7.82 |
| CHEMBL121605 | — | — | 1 | 7.80 |
| CHEMBL123394 | — | — | 1 | 7.77 |
| CHEMBL121422 | — | — | 1 | 7.77 |
| CHEMBL120111 | — | — | 1 | 7.77 |
| CHEMBL332393 | — | — | 1 | 7.75 |
| CHEMBL334242 | — | — | 1 | 7.72 |
| CHEMBL120909 | — | — | 1 | 7.68 |
| CHEMBL120553 | — | — | 1 | 7.68 |
| CHEMBL332532 | — | — | 1 | 7.64 |
| CHEMBL330844 | — | — | 1 | 7.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL121609 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL332993 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL121245 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL331755 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL121627 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL121617 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL332547 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL121645 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL332957 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL120112 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL414424 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL123182 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL123774 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL122736 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL123384 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL121030 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL330987 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL121481 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL420169 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL121199 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL121605 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL123394 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL121422 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL120111 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL332393 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL334242 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL120553 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL120909 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL332532 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL330844 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL331184 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL120850 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL338054 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL332073 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL119969 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL120884 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL121664 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL123343 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL123334 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL120899 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL121652 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL331678 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL333869 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL332877 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL122718 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL333803 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL120881 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL121152 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2111800 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL333691 | — | IC50 | = | 200.0 | nM | 6.70 |