Assay Detail
Binding
CHEMBL760953
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Inhibitory activity against recombinant human secretory phospholipase A2 (s-PLA2) by phosphatidylcholine/deoxycholate assay (PC/DOC).
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potent inhibitors of secretory phospholipase A2: synthesis and inhibitory activities of indolizine and indene derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 7.70 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL331755 | — | — | 1 | 8.89 |
| CHEMBL121627 | — | — | 1 | 8.85 |
| CHEMBL120112 | — | — | 1 | 8.52 |
| CHEMBL332547 | — | — | 1 | 8.52 |
| CHEMBL121245 | — | — | 1 | 8.52 |
| CHEMBL332993 | — | — | 1 | 8.52 |
| CHEMBL332957 | — | — | 1 | 8.38 |
| CHEMBL123774 | — | — | 1 | 8.30 |
| CHEMBL121617 | — | — | 1 | 8.30 |
| CHEMBL121645 | — | — | 1 | 8.22 |
| CHEMBL121422 | — | — | 1 | 8.14 |
| CHEMBL123182 | — | — | 1 | 7.96 |
| CHEMBL122736 | — | — | 1 | 7.89 |
| CHEMBL420169 | — | — | 1 | 7.89 |
| CHEMBL332393 | — | — | 1 | 7.89 |
| CHEMBL121481 | — | — | 1 | 7.85 |
| CHEMBL414424 | — | — | 1 | 7.82 |
| CHEMBL334242 | — | — | 1 | 7.72 |
| CHEMBL331184 | — | — | 1 | 7.70 |
| CHEMBL330987 | — | — | 1 | 7.66 |
| CHEMBL121609 | — | — | 1 | 7.62 |
| CHEMBL121030 | — | — | 1 | 7.58 |
| CHEMBL123384 | — | — | 1 | 7.55 |
| CHEMBL120553 | — | — | 1 | 7.52 |
| CHEMBL120909 | — | — | 1 | 7.52 |
| CHEMBL120899 | — | — | 1 | 7.31 |
| CHEMBL121199 | — | — | 1 | 7.28 |
| CHEMBL123394 | — | — | 1 | 7.11 |
| CHEMBL120884 | — | — | 1 | 7.10 |
| CHEMBL120850 | — | — | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL331755 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL121627 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL332547 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL121245 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL332993 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL120112 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL332957 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL123774 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL121617 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL121645 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL121422 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL123182 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL122736 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL420169 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL332393 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL121481 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL414424 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL334242 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL331184 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL330987 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL121609 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL121030 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL123384 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL120553 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL120909 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL120899 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL121199 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL123394 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL120884 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL120850 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL330844 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL119969 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL123343 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL338054 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL121664 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL332532 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL122718 | — | IC50 | = | 210.0 | nM | 6.68 |