Assay Detail

CHEMBL760955

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Binding

Inhibition of guinea pig phosphodiesterase type III

ChEMBL ↗

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Target

Phosphodiesterase 3 (CHEMBL2094125) ↗

Open DB target context

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Phosphodiesterase 3 (CHEMBL2094125) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Phosphodiesterase 3

CHEMBL2094125

Anchored from Assay target.

Protein identity Phosphodiesterase 3

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Cavia porcellus
Confidence	4 — Cell-line / Tissue
Curated By	Autocuration

Target

Phosphodiesterase 3 (CHEMBL2094125) ↗

Type	PROTEIN FAMILY
Organism	Homo sapiens

Publication

Cardiotonic agents. 3. Synthesis and biological activity of novel 6-(substituted 1H-imidazol-4(5)-yl)-3(2H)-pyridazinones.

Sircar I, Bobowski G, Bristol JA, Weishaar RE, Evans DB.
J Med Chem (1986) 29 : 261 -267
PubMed 3950907 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	5.21	5.21

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL12831	IMAZODAN	2.0	1	5.21

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL12831	IMAZODAN	IC50	=	6100.0	nM	5.21