Assay Detail
Binding
CHEMBL760957
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of low Km cyclic cAMP phosphodiesterase PDE III of guinea pig ventricle
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.26 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL440593 | CI-930 | — | 1 | 6.05 |
| CHEMBL12856 | INAMRINONE | 4.0 | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL440593 | CI-930 | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL12856 | INAMRINONE | IC50 | = | 35000.0 | nM | 4.46 |