Assay Detail
Binding
CHEMBL760997
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Inhibition of human platelet Phosphodiesterase 3
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and thromboxane synthesis inhibitory activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.27 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL189 | MILRINONE | 4.0 | 1 | 5.82 |
| CHEMBL555463 | — | — | 1 | 5.70 |
| CHEMBL118944 | — | — | 1 | 4.30 |
| CHEMBL544347 | — | — | 1 | - |
| CHEMBL72650 | — | — | 1 | - |
| CHEMBL117108 | — | — | 1 | - |
| CHEMBL119841 | — | — | 1 | - |
| CHEMBL544816 | — | — | 1 | - |
| CHEMBL118462 | — | — | 1 | - |
| CHEMBL539806 | — | — | 1 | - |
| CHEMBL28079 | ZAPRINAST | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL189 | MILRINONE | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL555463 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL118944 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL544347 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL72650 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL117108 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL119841 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL544816 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL118462 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL539806 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL28079 | ZAPRINAST | IC50 | = | 660000.0 | nM | - |